그 외 HPLC 컬럼류
10
DAICEL CHIRALPAK® ＆ CHIRALCEL®
DAICEL DAICEL HPLC Columns CHIRALCEL, CHIRALPAK, CROWNPAK Column은 enantiomeric 분석이나 Chiral Compound 분리에 사용되는 DAICEL Column입니다. Chiral Separation 분석 및 분취를 위한 최상의 Solution을 제공해 드립니다. 국, 내외로 Chiral 의약품 및 Chiral Compound에 대한 관심이 높아져 가고 있습니다. Chiral 중간체 제조와 Chiral Column 개발을 통하여 축적된 Chiral 분석 기술을 바탕으로 Chiral 분석을 위한 최상의 Solution을 제공해 드릴 것을 약속드립니다. 이처럼 분리체의 특성을 고려한 Column의 선택을 위해서 Flow Chart를 이용해서 분리할 수 있습니다. ◈ Odering information 제품명 규 격 P/N Type of Adsorbent Target 기본이동상 내경 (mm) 길이 (mm) 입경 (μm) CHIRALCEL OA 4.6 250 10 OA-2546 Cellulose tris-acetate Aromatic, Carbonyl, nitro, Sulfonyl, Cyano, Hydroxyl, Amine, Carboxylic acid group Hexane/ IPA 또는 Hexane/ EtOH CHIRALCEL OB 4.6 250 10 OB-2546 Cellulose tris-benzoate CHIRALCEL OB-H 4.6 150 5 OBH-1546 Cellulose tris-benzoate 4.6 250 5 OBH-2546 CHIRALCEL OC 4.6 250 10 OC-2546 Cellulose tris(phenylcarbamate) CHIRALCEL OD 4.6 250 10 OD-2546 Cellulose tris(3,5-dimethylphenylcarbamate) CHIRALCEL OD-H 4.6 150 5 ODH-1546 Cellulose tris(3,5-dimethylphenylcarbamate) 4.6 250 5 ODH-2546 CHIRALCEL OJ 4.6 250 10 OJ-2546 Cellulose tris(4-methylbenzoate) CHIRALCEL OJ-H 4.6 150 5 OJH-1546 Cellulose tris(4-methylbenzoate) 4.6 250 5 OJH-2546 CHIRALCEL OK 4.6 250 10 OK-2546 Cellulose tris-cinnimate CHIRALCEL OF 4.6 250 10 OF-2546 Cellulose tris(4-chlorophenylcarbamate) Hexane/ IPA CHIRALCEL OG 4.6 250 10 OG-2546 Cellulose tris(4-methylphenylcarbamate) CHIRALPAK AD 4.6 250 10 AD-2546 Amylose tris(3,5-dimethylphenylcarbamate) Hexane/ IPA 또는 Hexane/ EtOH CHIRALPAK AD-H 4.6 150 5 ADH-1546 Amylose tris(3,5-dimethylphenylcarbamate) 4.6 250 5 ADH-2546 CHIRALPAK AS 4.6 250 10 AS-2546 Amylose tris((s)-α-methylbenzylcarbamate) CHIRALPAK AS-H 4.6 150 5 ASH-1546 Amylose tris((s)-α-methylbenzylcarbamate) 4.6 250 5 ASH-2546 CHIRALPAK IA 4.6 150 5 IA-1546 Amylose tris(3,5-dimethylphenylcarbamate) 4.6 250 5 IA-2546 CHIRALPAK IB 4.6 150 5 IB-1546 Cellulose tris(3,5-dimethylphenylcarbamate) 4.6 250 5 IB-2546 CHIRALPAK IC 4.6 150 5 IC-1546 Amylose tris(3,5-dimethylphenylcarbamate) 4.6 250 5 IC-2546 CHIRALPAK AD-RH 4.6 150 5 ADRH-1546 Amylose tris(3,5-dimethylphenylcarbamate) 상기 화합물과 Amino acid Buffer/ ACN 또는 Buffer/ MeOH CHIRALPAK AS-RH 4.6 150 5 ASRH-1546 Amylose tris((s)-α-methylbenzylcarbamate) CHIRALCEL OJ-RH 4.6 150 5 OJRH-1546 Cellulose tris(4-methylbenzoate) CHIRALCEL OD-R 4.6 250 10 OJRH-2546 Cellulose tris(3,5-dimethylphenylcarbamate) CHIRALCEL OD-RH 4.6 150 5 ODRH-1546 Cellulose tris(3,5-dimethylphenylcarbamate) CHIRALPAK OT(+) 4.6 250 10 OT-2546 Poly(triphenylmethyl methacrylate) Aromatic (방향족기) Hexane/ IPA 또는 MeOH CHIRALPAK OP(+) 4.6 250 10 OP-2546 Poly(diphenyl-2-pyridyllmethyl methacrylate) CHIRALPAK WH 4.6 250 10 WH-2546 Binded L-amino acid Amino acids (아미노산 또는 아미노산유도체) Aq. CuSO4 CHIRALPAK MA(+) 4.6 50 3 MA-0546 Coated L-amino acid Hydroxy Carboxylic acids (카르본산) CHIRALPAKQD-AX 4.6 150 5 QDAX-1546 O-9-(tert-butylcarbamoyl) quinidine carboxylic, phosphonic, phosphinic, phosphiric, sulfonic acid group methanoal, acetonitrile, tetrahydrofuran ,1,4-dioxane, chloroform CHIRALPAK QN-AX 4.6 150 5 QNAX-1546 O-9-(tert-butylcarbamoyl) quinine CROWNPAK CR(+) 4.0 150 5 CR(+)-1540 CrownEther NH2 Group (아미노기) Aq. HCIO4 CROWNPAK CR(-) 4.0 150 5 CR(-)-1540 CrownEther 예일테크 2013.04.25
DAICEL DAICEL HPLC Columns CHIRALCEL, CHIRALPAK, CROWNPAK Column은 enantiomeric 분석이나 Chiral Compound 분리에 사용되는 DAICEL Column입니다. Chiral Separation 분석 및 분취를 위한 최상의 Solution을 제공해 드립니다. 국, 내외로 Chiral 의약품 및 Chiral Compound에 대한 관심이 높아져 가고 있습니다. Chiral 중간체 제조와 Chiral Column 개발을 통하여 축적된 Chiral 분석 기술을 바탕으로 Chiral 분석을 위한 최상의 Solution을 제공해 드릴 것을 약속드립니다. 이처럼 분리체의 특성을 고려한 Column의 선택을 위해서 Flow Chart를 이용해서 분리할 수 있습니다. ◈ Odering information 제품명 규 격 P/N Type of Adsorbent Target 기본이동상 내경 (mm) 길이 (mm) 입경 (μm) CHIRALCEL OA 4.6 250 10 OA-2546 Cellulose tris-acetate Aromatic, Carbonyl, nitro, Sulfonyl, Cyano, Hydroxyl, Amine, Carboxylic acid group Hexane/ IPA 또는 Hexane/ EtOH CHIRALCEL OB 4.6 250 10 OB-2546 Cellulose tris-benzoate CHIRALCEL OB-H 4.6 150 5 OBH-1546 Cellulose tris-benzoate 4.6 250 5 OBH-2546 CHIRALCEL OC 4.6 250 10 OC-2546 Cellulose tris(phenylcarbamate) CHIRALCEL OD 4.6 250 10 OD-2546 Cellulose tris(3,5-dimethylphenylcarbamate) CHIRALCEL OD-H 4.6 150 5 ODH-1546 Cellulose tris(3,5-dimethylphenylcarbamate) 4.6 250 5 ODH-2546 CHIRALCEL OJ 4.6 250 10 OJ-2546 Cellulose tris(4-methylbenzoate) CHIRALCEL OJ-H 4.6 150 5 OJH-1546 Cellulose tris(4-methylbenzoate) 4.6 250 5 OJH-2546 CHIRALCEL OK 4.6 250 10 OK-2546 Cellulose tris-cinnimate CHIRALCEL OF 4.6 250 10 OF-2546 Cellulose tris(4-chlorophenylcarbamate) Hexane/ IPA CHIRALCEL OG 4.6 250 10 OG-2546 Cellulose tris(4-methylphenylcarbamate) CHIRALPAK AD 4.6 250 10 AD-2546 Amylose tris(3,5-dimethylphenylcarbamate) Hexane/ IPA 또는 Hexane/ EtOH CHIRALPAK AD-H 4.6 150 5 ADH-1546 Amylose tris(3,5-dimethylphenylcarbamate) 4.6 250 5 ADH-2546 CHIRALPAK AS 4.6 250 10 AS-2546 Amylose tris((s)-α-methylbenzylcarbamate) CHIRALPAK AS-H 4.6 150 5 ASH-1546 Amylose tris((s)-α-methylbenzylcarbamate) 4.6 250 5 ASH-2546 CHIRALPAK IA 4.6 150 5 IA-1546 Amylose tris(3,5-dimethylphenylcarbamate) 4.6 250 5 IA-2546 CHIRALPAK IB 4.6 150 5 IB-1546 Cellulose tris(3,5-dimethylphenylcarbamate) 4.6 250 5 IB-2546 CHIRALPAK IC 4.6 150 5 IC-1546 Amylose tris(3,5-dimethylphenylcarbamate) 4.6 250 5 IC-2546 CHIRALPAK AD-RH 4.6 150 5 ADRH-1546 Amylose tris(3,5-dimethylphenylcarbamate) 상기 화합물과 Amino acid Buffer/ ACN 또는 Buffer/ MeOH CHIRALPAK AS-RH 4.6 150 5 ASRH-1546 Amylose tris((s)-α-methylbenzylcarbamate) CHIRALCEL OJ-RH 4.6 150 5 OJRH-1546 Cellulose tris(4-methylbenzoate) CHIRALCEL OD-R 4.6 250 10 OJRH-2546 Cellulose tris(3,5-dimethylphenylcarbamate) CHIRALCEL OD-RH 4.6 150 5 ODRH-1546 Cellulose tris(3,5-dimethylphenylcarbamate) CHIRALPAK OT(+) 4.6 250 10 OT-2546 Poly(triphenylmethyl methacrylate) Aromatic (방향족기) Hexane/ IPA 또는 MeOH CHIRALPAK OP(+) 4.6 250 10 OP-2546 Poly(diphenyl-2-pyridyllmethyl methacrylate) CHIRALPAK WH 4.6 250 10 WH-2546 Binded L-amino acid Amino acids (아미노산 또는 아미노산유도체) Aq. CuSO4 CHIRALPAK MA(+) 4.6 50 3 MA-0546 Coated L-amino acid Hydroxy Carboxylic acids (카르본산) CHIRALPAKQD-AX 4.6 150 5 QDAX-1546 O-9-(tert-butylcarbamoyl) quinidine carboxylic, phosphonic, phosphinic, phosphiric, sulfonic acid group methanoal, acetonitrile, tetrahydrofuran ,1,4-dioxane, chloroform CHIRALPAK QN-AX 4.6 150 5 QNAX-1546 O-9-(tert-butylcarbamoyl) quinine CROWNPAK CR(+) 4.0 150 5 CR(+)-1540 CrownEther NH2 Group (아미노기) Aq. HCIO4 CROWNPAK CR(-) 4.0 150 5 CR(-)-1540 CrownEther 예일테크 2013.04.25
9
Chiral-AGP Columns
Chiral-AGP Columns
◈ Product Information
Chiral-AGP는 카이랄분리상과 같은 α₁-acid glycoprotein(AGP) 사용에 기초한 제2의 일반적인 카이럴 분리컬럼이다.
독특한 과정을 통하여 α₁-AGP는 다공성의 구형 실리카 입자(5㎛)에 고정되며, 실리카의 화학적표면은 폭넓은 적용범위로 안정된 카이랄 분리 물질을 제공한다.
- 폭넓은 적용범위
- 산성, 염기성, 중성
- No derivatization (유도체화반응 없음)
► Point
• Enantioselectivity
라세믹 아민, 산, 가수분해되지않는 화합물은 유도체화반응없이 직접 분석할 수 있다.
이 컬럼은 화합물 종류가 다른 수많은 카이랄 화합물의 분리능을 가능하게 한다,
이것은 카이랄 고정상의 독특한 성질때문이며, Enantioselectivity가 적당한 이동상 혼합물 선택을 유도할 수 있다.
• Chromatographic Conditions
유기화합물 첨가제의 첨가와 함께 인산염 완충제는 이동상에 사용된다.
(1,2-propenol과 acetonitrile은 가장 자주 첨가제로 사용된다.)
Enantioselectivity과 머무름은 이동상화합물이 바뀜에 따라 조정될 수 있다.
(pH, 농도 혹은 유기적첨가제의 특성). 컬럼온도는 또한 이런 변수에 의해 영향을 준다.
• Storage Conditions
컬럼은 실온이나 그 이하의 온도에 두어야 한다. 짧은 기간의 보관(즉, 일주일)동안 10%의 2-propanol 수용액으로
컬럼을 채우기를 권장한다.
컬럼을 오랜시간 보관해야 할 때는 15%의 2-propanol 수용액으로 컬럼을 채우고, 냉장보관을 권장한다.
• Cleaning of the Column
컬럼이 소수성물질에 오염되었다면 0.2ml/min 유속으로 25%의 2-propanol 수용액을 하룻밤정도 흘려서 세정한다.
► Chromatography
• Fendiline
• Ibuprofen
◈ Ordering Information Description Size
(mm) Particle
Size(μm) Chiral-AGP 4.0 x 50 5 Chiral-AGP 4.0 x 100 5 Chiral-AGP 4.0 x 150 5 Chiral-AGP guard cart,2/pk 4.0 x 10 Chiral-AGP 3.0 x 50 5 Chiral-AGP 3.0 x 100 5 Chiral-AGP 3.0 x 150 5 Chiral-AGP guard cart,2/pk 3.0 x 10 Chiral-AGP 2.0 x 50 5 Chiral-AGP 2.0 x 100 5 Chiral-AGP 2.0 x 150 5 Chiral-AGP guard cart,2/pk 2.0 x 10 Chiral-AGP 10.0 x 100 5 Chiral-AGP 10.0 x 150 5 Guard Cartridge holder 예일테크 2008.12.17
Chiral-AGP Columns
◈ Product Information
Chiral-AGP는 카이랄분리상과 같은 α₁-acid glycoprotein(AGP) 사용에 기초한 제2의 일반적인 카이럴 분리컬럼이다.
독특한 과정을 통하여 α₁-AGP는 다공성의 구형 실리카 입자(5㎛)에 고정되며, 실리카의 화학적표면은 폭넓은 적용범위로 안정된 카이랄 분리 물질을 제공한다.
- 폭넓은 적용범위
- 산성, 염기성, 중성
- No derivatization (유도체화반응 없음)
► Point
• Enantioselectivity
라세믹 아민, 산, 가수분해되지않는 화합물은 유도체화반응없이 직접 분석할 수 있다.
이 컬럼은 화합물 종류가 다른 수많은 카이랄 화합물의 분리능을 가능하게 한다,
이것은 카이랄 고정상의 독특한 성질때문이며, Enantioselectivity가 적당한 이동상 혼합물 선택을 유도할 수 있다.
• Chromatographic Conditions
유기화합물 첨가제의 첨가와 함께 인산염 완충제는 이동상에 사용된다.
(1,2-propenol과 acetonitrile은 가장 자주 첨가제로 사용된다.)
Enantioselectivity과 머무름은 이동상화합물이 바뀜에 따라 조정될 수 있다.
(pH, 농도 혹은 유기적첨가제의 특성). 컬럼온도는 또한 이런 변수에 의해 영향을 준다.
• Storage Conditions
컬럼은 실온이나 그 이하의 온도에 두어야 한다. 짧은 기간의 보관(즉, 일주일)동안 10%의 2-propanol 수용액으로
컬럼을 채우기를 권장한다.
컬럼을 오랜시간 보관해야 할 때는 15%의 2-propanol 수용액으로 컬럼을 채우고, 냉장보관을 권장한다.
• Cleaning of the Column
컬럼이 소수성물질에 오염되었다면 0.2ml/min 유속으로 25%의 2-propanol 수용액을 하룻밤정도 흘려서 세정한다.
► Chromatography
• Fendiline
• Ibuprofen
◈ Ordering Information Description Size
(mm) Particle
Size(μm) Chiral-AGP 4.0 x 50 5 Chiral-AGP 4.0 x 100 5 Chiral-AGP 4.0 x 150 5 Chiral-AGP guard cart,2/pk 4.0 x 10 Chiral-AGP 3.0 x 50 5 Chiral-AGP 3.0 x 100 5 Chiral-AGP 3.0 x 150 5 Chiral-AGP guard cart,2/pk 3.0 x 10 Chiral-AGP 2.0 x 50 5 Chiral-AGP 2.0 x 100 5 Chiral-AGP 2.0 x 150 5 Chiral-AGP guard cart,2/pk 2.0 x 10 Chiral-AGP 10.0 x 100 5 Chiral-AGP 10.0 x 150 5 Guard Cartridge holder 예일테크 2008.12.17
8
Shinwa Chemical Ultron Chiral Columns
Ultron Chiral Columns
◈ Product Information
Ultron ES-OVM 은 chiral isomers(enantiomeric compounds)를 분석하는 컬럼입니다. Chiral isomers는 화학적인 구조식이 독특하여 HPLC Column으로는 분석이 되지않습니다. Ultron ES-OVM column 은 Chiral 성분들을 인식하는 많은 성분들을 Packing Material로 포함하고 있어 넓은 범위의 enantiomeric compounds 분석적용이 가능합니다. 또한 수소결합, 극성도, 이온성, 비극성 성분 뿐만 아니라 3차원 분자구조 까지 인식이 가능합니다.
► Point
• Direct racemic separations without derivatization
• Use Ultron ES-OVM to separate enantiomers of pharmaceuticals, such as hexobarbital, ibuprofen, and profenamine
• Ultron ES-Pepsin Chiral columns are best suited to separate basic compounds that aredifficult to separate by other columns
• ES-OVM and ES-Pepsin columns contain 120Å, 5 μm silica particles bonded with an ovomucoid protein and pepsin protein, respectively
• Both types of chiral columns are usable with reversed-phase mobile phases such as acetonitrile or ethanol and phosphate buffer
► Chromatography
◈ Ordering Information Description Size
(mm) Particle
Size(μm) P/N ES-OVM ES-Pepsin Semi-Prep 10 x 150 5 722111723 Analytical 4.6 x 250 10 724111653 Analytical 4.6 x 150 5 702111651 822111651 Analytical, with Guard 4.6 x 150 5 702111651A 822111631A Narrow Bore 2.0 x 150 5 702111610 Guard Column 4.0 x 10 5 712111630 832111630 예일테크 2008.07.31
Ultron Chiral Columns
◈ Product Information
Ultron ES-OVM 은 chiral isomers(enantiomeric compounds)를 분석하는 컬럼입니다. Chiral isomers는 화학적인 구조식이 독특하여 HPLC Column으로는 분석이 되지않습니다. Ultron ES-OVM column 은 Chiral 성분들을 인식하는 많은 성분들을 Packing Material로 포함하고 있어 넓은 범위의 enantiomeric compounds 분석적용이 가능합니다. 또한 수소결합, 극성도, 이온성, 비극성 성분 뿐만 아니라 3차원 분자구조 까지 인식이 가능합니다.
► Point
• Direct racemic separations without derivatization
• Use Ultron ES-OVM to separate enantiomers of pharmaceuticals, such as hexobarbital, ibuprofen, and profenamine
• Ultron ES-Pepsin Chiral columns are best suited to separate basic compounds that aredifficult to separate by other columns
• ES-OVM and ES-Pepsin columns contain 120Å, 5 μm silica particles bonded with an ovomucoid protein and pepsin protein, respectively
• Both types of chiral columns are usable with reversed-phase mobile phases such as acetonitrile or ethanol and phosphate buffer
► Chromatography
◈ Ordering Information Description Size
(mm) Particle
Size(μm) P/N ES-OVM ES-Pepsin Semi-Prep 10 x 150 5 722111723 Analytical 4.6 x 250 10 724111653 Analytical 4.6 x 150 5 702111651 822111651 Analytical, with Guard 4.6 x 150 5 702111651A 822111631A Narrow Bore 2.0 x 150 5 702111610 Guard Column 4.0 x 10 5 712111630 832111630 예일테크 2008.07.31
7
Merck Purospher®
Purospher®
◈ Product Information
Purospher® HPLC columns are based upon a high-purity, metal free silica for excellent separations with very good peak symmetry.
The base material for Purospher® high-purity HPLC columns is made from tetraalkoxysilane.
Due to the absence of heavy metals in the silica matrix and in combination with a complete coverage of the silica surface, this stationary phase enables tailing-free chromatography of acidic, basic and chelating compounds. This is of particular advantage for method development.
The Purospher® product family comprises three different Purospher® HPLC packing materials:
► Purospher® RP-18
Purospher® RP-18 is polar endcapped and suitable for separations of strong basic or chelating compounds(no acidic compounds) and separations of hydrophilic compounds with a high percentage ofwater in the mobile phase.
► Purospher® RP-18 endcapped
Purospher® RP-18 endcapped is suitable for separations of complex samples with simple eluents.
► Purospher® RP-18 HC
Purospher® RP-18 HC is not endcapped with very good suitability for separation of polar, not basiccompounds e.g. explosives.
► Purospher® STAR
Purospher® STAR is the latest development of Merck's particulate HPLC sorbents and allows separationsof neutral, acidic, basic or chelating compounds. The excellent stability up to pH 10.5 allows the separation of strong basic compounds with alkaline eluents. The wide range of sorbents allows method development of all applications.
Available Purospher® STAR sorbents are: RP-18 endcapped (3μm or 5μm); RP-8 endcapped (3μm or 5μm); NH2, 5μm and Si, 5μm.
◈ Ordering Information
(* 전체 제품중 일부만 표기-Merck 전제품 공급가능) 예일테크 2008.07.30
Purospher®
◈ Product Information
Purospher® HPLC columns are based upon a high-purity, metal free silica for excellent separations with very good peak symmetry.
The base material for Purospher® high-purity HPLC columns is made from tetraalkoxysilane.
Due to the absence of heavy metals in the silica matrix and in combination with a complete coverage of the silica surface, this stationary phase enables tailing-free chromatography of acidic, basic and chelating compounds. This is of particular advantage for method development.
The Purospher® product family comprises three different Purospher® HPLC packing materials:
► Purospher® RP-18
Purospher® RP-18 is polar endcapped and suitable for separations of strong basic or chelating compounds(no acidic compounds) and separations of hydrophilic compounds with a high percentage ofwater in the mobile phase.
► Purospher® RP-18 endcapped
Purospher® RP-18 endcapped is suitable for separations of complex samples with simple eluents.
► Purospher® RP-18 HC
Purospher® RP-18 HC is not endcapped with very good suitability for separation of polar, not basiccompounds e.g. explosives.
► Purospher® STAR
Purospher® STAR is the latest development of Merck's particulate HPLC sorbents and allows separationsof neutral, acidic, basic or chelating compounds. The excellent stability up to pH 10.5 allows the separation of strong basic compounds with alkaline eluents. The wide range of sorbents allows method development of all applications.
Available Purospher® STAR sorbents are: RP-18 endcapped (3μm or 5μm); RP-8 endcapped (3μm or 5μm); NH2, 5μm and Si, 5μm.
◈ Ordering Information
(* 전체 제품중 일부만 표기-Merck 전제품 공급가능) 예일테크 2008.07.30
6
Merck LiChrospher®
LiChrospher®
◈ Product Information
LiChrospher® are reliable and versatile traditionally produced spherical silica carrier.
LiChrospher® silica carrier are available with different modifications.
The polar modified phases LiChrospher® CN, LiChrospher® NH2 and LiChrospher® DIOL as well as LiChrospher® Si with no modification are best for normal phase HPLC.
Furthermore LiChrospher® PAH is highly efficient and selective for the separation of PAH; as well as LiChrospher® WP 300 RP-18 for the separation of peptides and low molecular weight proteins.
LiChrospher® packing materials are available as Hibar® RT column and as LiChroCART® cartridge in different lengths and different internal diameters (10 mm, 4 mm, 3 mm and 2 mm).
LiChroCART® 3 mm i.d. and 2 mm i.d. narrow bore cartridges for HPLC saves costs by reducing the solvent consumption and allows the handling of very small quantities while increased sensitivity as well as resolution are achieved.
LiChroCART® cartridges 4 mm i.d., 3 mm i.d. and 2 mm i.d. are compatible to the manuCART® "4" this facilitate faster and more flexible method adaptation to smaller bore columns.
LiChroCART® cartridges 10 mm i.d. have to be used with manuCART "10"-II.
(* 전체 제품중 일부만 표기-Merck 전제품 공급가능) 예일테크 2008.07.25
LiChrospher®
◈ Product Information
LiChrospher® are reliable and versatile traditionally produced spherical silica carrier.
LiChrospher® silica carrier are available with different modifications.
The polar modified phases LiChrospher® CN, LiChrospher® NH2 and LiChrospher® DIOL as well as LiChrospher® Si with no modification are best for normal phase HPLC.
Furthermore LiChrospher® PAH is highly efficient and selective for the separation of PAH; as well as LiChrospher® WP 300 RP-18 for the separation of peptides and low molecular weight proteins.
LiChrospher® packing materials are available as Hibar® RT column and as LiChroCART® cartridge in different lengths and different internal diameters (10 mm, 4 mm, 3 mm and 2 mm).
LiChroCART® 3 mm i.d. and 2 mm i.d. narrow bore cartridges for HPLC saves costs by reducing the solvent consumption and allows the handling of very small quantities while increased sensitivity as well as resolution are achieved.
LiChroCART® cartridges 4 mm i.d., 3 mm i.d. and 2 mm i.d. are compatible to the manuCART® "4" this facilitate faster and more flexible method adaptation to smaller bore columns.
LiChroCART® cartridges 10 mm i.d. have to be used with manuCART "10"-II.
(* 전체 제품중 일부만 표기-Merck 전제품 공급가능) 예일테크 2008.07.25
5
Merck LiChrosorb®
LiChrosorb®
◈ Product Information
LiChrosorb® is one of the most successful and reliable packing materials used in HPLC for more than 25 years and documented in literature in the form of several thousand applications.
The totally porous irregular particles are finely classified in the 5, 7 and 10 μm range.
LiChrosorb® packing materials offers the compete programme of non-polar derivatives (RP-8, RP-18, RP-select B) polar derivatives (Si 60 and Si 100) and derivatives of medium polarity (NH2, CN and DIOL).
Additionally to the analytical cartridges and columns like LiChroCART® 250-4 or Hibar® RT 250-4 Merck offers semi-preparative cartridges LiChroCART® 250-10 as well as Hibar® RT columns 250-10 and packed with different LiChrosorb® packing materials on request.
예일테크 2008.07.25
LiChrosorb®
◈ Product Information
LiChrosorb® is one of the most successful and reliable packing materials used in HPLC for more than 25 years and documented in literature in the form of several thousand applications.
The totally porous irregular particles are finely classified in the 5, 7 and 10 μm range.
LiChrosorb® packing materials offers the compete programme of non-polar derivatives (RP-8, RP-18, RP-select B) polar derivatives (Si 60 and Si 100) and derivatives of medium polarity (NH2, CN and DIOL).
Additionally to the analytical cartridges and columns like LiChroCART® 250-4 or Hibar® RT 250-4 Merck offers semi-preparative cartridges LiChroCART® 250-10 as well as Hibar® RT columns 250-10 and packed with different LiChrosorb® packing materials on request.
예일테크 2008.07.25
4
GL Science Inertsil®
Inertsil®
◈ Product Information
► HPLC용으로 개발된 고성능 실리카겔
Inertsil 3 시리즈에 이용하고 있는 실리카겔은 HPLC용으로 개발된 표면적450m2/g, Pore size 100A 고순도 실리카겔입니다. 기존의 HPLC용 실리카겔에서 나타나는 표면의 요철이나, 균열 등이 있는 실리카겔이 아니며, 높은 재현성을 얻을 수 있습니다.
► 낮은 분석 압력
고성능 실리카겔이기 때문에 압력 변동에 강하고 낮은 압력으로 이상적인이론 단수를 얻을 수 있습니다. 분석 압력은 실리카겔의 물리 형상, 입도 분포, 화학 결합기종, 화학 결합량의 영향을 크게 받습니다.
► 분석 방법 개발에 적절한 여러종류의 컬럼
100A 실리카겔의 모체로서는 2종의 ODS(Inertsil ODS-3, ODS-P), 옥틸기 결합 타입(Inertsil C8-3), 페닐기 결합 타입(Inertsil Ph-3), 시아노기 결합 타입(Inertsil CN-3), 화학 처리가 없는 실리카겔(Inertsil SIL-100A)의 6종류가 있습니다. 그리고 충전 컬럼으로서 내경 0.05~0.3mm의 capillary 컬럼, 내경 1~4.6mm까지의 마이크로, 세미마이크로, 범용 컬럼, 고속 분석에 최적인 Combi-chem short 컬럼, 컬럼 보호에 유효해 사용하기 쉬운 카트리지 방식 가드 컬럼, 내경 6mm~50mm의 세미 분취, 분취 컬럼 등 다양한 컬럼 종류를 준비해 두고 있기 때문에 컬럼 사이즈의 변경에도 안심하고 대처할 수 있어 분석 방법 개발에 적절하다고 할 수 있습니다.
Inertsil 실리카겔 화학처리 surface Area
m2/g Pore size
A Pore volume
mL/g Particle size
um Bonded
Phase Carbon Load
% End
Capping ODS-3 450 100 1.05 3, 5 Octadecyl 15 YES ODS-3V 5 Octadecyl 15 YES ODS-P 5 Octadecyl 29 NO C8-3 3, 5 Octyl 9 YES Ph-3 3, 5 Phenyl 9.5 NO CN-3 5 Cyanopropyl 14 NO SIL-100A 3, 5 NO
► 어려운 품질 검사에서 증명된 높은 재현성
1. 전자현미경에 의한 실리카겔 검사
2. 실리카겔 모체의 물성치(Particle size, Surface Area, Pore size, Pore volume)
3. 모체 실리카겔 불순물 검사
4. 잔존 Silanol검사
5. 충전제 Lot마다의 크로마토그램 검사
6. 충전 컬럼 평가 시험
► 선택성 검사
충전제 고유의 성질을 조사하기 위해서 선택성 검사를 실시.
충전제 Lot마다 보관, 유지패턴의 불균형이 없는 것을 알 수 있음.
► 알칼리성 시료에 대한 충전제의 불활성도 검사
충전제의 불활성도를 염기 화합물의 대표인 Pyridine을 이용해 흡착이 생기기 쉬운 물/메타놀 용액으로 검사를 행함.
► 금속 화합물에 대한 충전제의 불활성도 검사
► 높은 내구성
◈ Ordering Information Phase Particle
Size Pore
Size ID X Length Part No. ODS-3 3um 100A 4.0 x 150mm 5020-04435 ODS-3 3um 100A 4.0 x 250mm 5020-04436 ODS-3 3um 100A 4.6 x 150mm 5020-01771 ODS-3 3um 100A 4.6 x 250mm 5020-01772 ODS-3 5um 100A 4.0 x 150mm 5020-01761 ODS-3 5um 100A 4.0 x 250mm 5020-01762 ODS-3 5um 100A 4.6 x 150mm 5020-01731 ODS-3 5um 100A 4.6 x 250mm 5020-01732 ODS-2 5um 150A 4.0 x 150mm 5020-01101-40 ODS-2 5um 150A 4.0 x 250mm 5020-01102-40 ODS-2 5um 150A 4.6 x 150mm 5020-01101-46 ODS-2 5um 150A 4.6 x 250mm 5020-01102-46 ODS-3V 5um 100A 4.0 x 150mm 5020-01811 ODS-3V 5um 100A 4.0 x 250mm 5020-01812 ODS-3V 5um 100A 4.6 x 150mm 5020-01801 ODS-3V 5um 100A 4.6 x 250mm 5020-01802 ODS-P 5um 100A 4.0 x 150mm 5020-04735 ODS-P 5um 100A 4.0 x 250mm 5020-04736 ODS-P 5um 100A 4.6 x 150mm 5020-02001 ODS-P 5um 100A 4.6 x 250mm 5020-02002 C8-3 3um 100A 4.0 x 150mm 5020-04835 C8-3 3um 100A 4.0 x 250mm 5020-04836 C8-3 3um 100A 4.6 x 150mm 5020-01911 C8-3 3um 100A 4.6 x 250mm 5020-01912 C8-3 5um 100A 4.0 x 150mm 5020-01902 C8-3 5um 100A 4.0 x 250mm 5020-01903 C8-3 5um 100A 4.6 x 150mm 5020-01900 C8-3 5um 100A 4.6 x 250mm 5020-01901 Ph-3 3um 100A 4.0 x 150mm 5020-05035 Ph-3 3um 100A 4.0 x 250mm 5020-05036 Ph-3 3um 100A 4.6 x 150mm 5020-01931 Ph-3 3um 100A 4.6 x 250mm 5020-01932 Ph-3 5um 100A 4.0 x 150mm 5020-01922 Ph-3 5um 100A 4.0 x 250mm 5020-01923 Ph-3 5um 100A 4.6 x 150mm 5020-01920 Ph-3 5um 100A 4.6 x 250mm 5020-01921 Diol 5um 100A 4.0 x 150mm 5020-05635 Diol 5um 100A 4.0 x 250mm 5020-05636 Diol 5um 100A 4.6 x 150mm 5020-05645 Diol 5um 100A 4.6 x 250mm 5020-05646 CN-3 5um 100A 4.0 x 150mm 5020-01942 CN-3 5um 100A 4.0 x 250mm 5020-01943 CN-3 5um 100A 4.6 x 150mm 5020-01940 CN-3 5um 100A 4.6 x 250mm 5020-01941 NH2 5um 100A 4.0 x 150mm 5020-05535 NH2 5um 100A 4.0 x 250mm 5020-05536 NH2 5um 100A 4.6 x 150mm 5020-05545 NH2 5um 100A 4.6 x 250mm 5020-05546 SIL-100A 3um 100A 4.0 x 150mm 5020-04235 SIL-100A 3um 100A 4.0 x 250mm 5020-04236 SIL-100A 3um 100A 4.6 x 150mm 5020-01701 SIL-100A 3um 100A 4.6 x 250mm 5020-01702 SIL-100A 5um 100A 4.0 x 150mm 5020-04335 SIL-100A 5um 100A 4.0 x 250mm 5020-04336 SIL-100A 5um 100A 4.6 x 150mm 5020-01711 SIL-100A 5um 100A 4.6 x 250mm 5020-01712
(* 전체 제품중 일부만 표기-Inertsil 전제품 공급가능) 예일테크 2008.07.18
Inertsil®
◈ Product Information
► HPLC용으로 개발된 고성능 실리카겔
Inertsil 3 시리즈에 이용하고 있는 실리카겔은 HPLC용으로 개발된 표면적450m2/g, Pore size 100A 고순도 실리카겔입니다. 기존의 HPLC용 실리카겔에서 나타나는 표면의 요철이나, 균열 등이 있는 실리카겔이 아니며, 높은 재현성을 얻을 수 있습니다.
► 낮은 분석 압력
고성능 실리카겔이기 때문에 압력 변동에 강하고 낮은 압력으로 이상적인이론 단수를 얻을 수 있습니다. 분석 압력은 실리카겔의 물리 형상, 입도 분포, 화학 결합기종, 화학 결합량의 영향을 크게 받습니다.
► 분석 방법 개발에 적절한 여러종류의 컬럼
100A 실리카겔의 모체로서는 2종의 ODS(Inertsil ODS-3, ODS-P), 옥틸기 결합 타입(Inertsil C8-3), 페닐기 결합 타입(Inertsil Ph-3), 시아노기 결합 타입(Inertsil CN-3), 화학 처리가 없는 실리카겔(Inertsil SIL-100A)의 6종류가 있습니다. 그리고 충전 컬럼으로서 내경 0.05~0.3mm의 capillary 컬럼, 내경 1~4.6mm까지의 마이크로, 세미마이크로, 범용 컬럼, 고속 분석에 최적인 Combi-chem short 컬럼, 컬럼 보호에 유효해 사용하기 쉬운 카트리지 방식 가드 컬럼, 내경 6mm~50mm의 세미 분취, 분취 컬럼 등 다양한 컬럼 종류를 준비해 두고 있기 때문에 컬럼 사이즈의 변경에도 안심하고 대처할 수 있어 분석 방법 개발에 적절하다고 할 수 있습니다.
Inertsil 실리카겔 화학처리 surface Area
m2/g Pore size
A Pore volume
mL/g Particle size
um Bonded
Phase Carbon Load
% End
Capping ODS-3 450 100 1.05 3, 5 Octadecyl 15 YES ODS-3V 5 Octadecyl 15 YES ODS-P 5 Octadecyl 29 NO C8-3 3, 5 Octyl 9 YES Ph-3 3, 5 Phenyl 9.5 NO CN-3 5 Cyanopropyl 14 NO SIL-100A 3, 5 NO
► 어려운 품질 검사에서 증명된 높은 재현성
1. 전자현미경에 의한 실리카겔 검사
2. 실리카겔 모체의 물성치(Particle size, Surface Area, Pore size, Pore volume)
3. 모체 실리카겔 불순물 검사
4. 잔존 Silanol검사
5. 충전제 Lot마다의 크로마토그램 검사
6. 충전 컬럼 평가 시험
► 선택성 검사
충전제 고유의 성질을 조사하기 위해서 선택성 검사를 실시.
충전제 Lot마다 보관, 유지패턴의 불균형이 없는 것을 알 수 있음.
► 알칼리성 시료에 대한 충전제의 불활성도 검사
충전제의 불활성도를 염기 화합물의 대표인 Pyridine을 이용해 흡착이 생기기 쉬운 물/메타놀 용액으로 검사를 행함.
► 금속 화합물에 대한 충전제의 불활성도 검사
► 높은 내구성
◈ Ordering Information Phase Particle
Size Pore
Size ID X Length Part No. ODS-3 3um 100A 4.0 x 150mm 5020-04435 ODS-3 3um 100A 4.0 x 250mm 5020-04436 ODS-3 3um 100A 4.6 x 150mm 5020-01771 ODS-3 3um 100A 4.6 x 250mm 5020-01772 ODS-3 5um 100A 4.0 x 150mm 5020-01761 ODS-3 5um 100A 4.0 x 250mm 5020-01762 ODS-3 5um 100A 4.6 x 150mm 5020-01731 ODS-3 5um 100A 4.6 x 250mm 5020-01732 ODS-2 5um 150A 4.0 x 150mm 5020-01101-40 ODS-2 5um 150A 4.0 x 250mm 5020-01102-40 ODS-2 5um 150A 4.6 x 150mm 5020-01101-46 ODS-2 5um 150A 4.6 x 250mm 5020-01102-46 ODS-3V 5um 100A 4.0 x 150mm 5020-01811 ODS-3V 5um 100A 4.0 x 250mm 5020-01812 ODS-3V 5um 100A 4.6 x 150mm 5020-01801 ODS-3V 5um 100A 4.6 x 250mm 5020-01802 ODS-P 5um 100A 4.0 x 150mm 5020-04735 ODS-P 5um 100A 4.0 x 250mm 5020-04736 ODS-P 5um 100A 4.6 x 150mm 5020-02001 ODS-P 5um 100A 4.6 x 250mm 5020-02002 C8-3 3um 100A 4.0 x 150mm 5020-04835 C8-3 3um 100A 4.0 x 250mm 5020-04836 C8-3 3um 100A 4.6 x 150mm 5020-01911 C8-3 3um 100A 4.6 x 250mm 5020-01912 C8-3 5um 100A 4.0 x 150mm 5020-01902 C8-3 5um 100A 4.0 x 250mm 5020-01903 C8-3 5um 100A 4.6 x 150mm 5020-01900 C8-3 5um 100A 4.6 x 250mm 5020-01901 Ph-3 3um 100A 4.0 x 150mm 5020-05035 Ph-3 3um 100A 4.0 x 250mm 5020-05036 Ph-3 3um 100A 4.6 x 150mm 5020-01931 Ph-3 3um 100A 4.6 x 250mm 5020-01932 Ph-3 5um 100A 4.0 x 150mm 5020-01922 Ph-3 5um 100A 4.0 x 250mm 5020-01923 Ph-3 5um 100A 4.6 x 150mm 5020-01920 Ph-3 5um 100A 4.6 x 250mm 5020-01921 Diol 5um 100A 4.0 x 150mm 5020-05635 Diol 5um 100A 4.0 x 250mm 5020-05636 Diol 5um 100A 4.6 x 150mm 5020-05645 Diol 5um 100A 4.6 x 250mm 5020-05646 CN-3 5um 100A 4.0 x 150mm 5020-01942 CN-3 5um 100A 4.0 x 250mm 5020-01943 CN-3 5um 100A 4.6 x 150mm 5020-01940 CN-3 5um 100A 4.6 x 250mm 5020-01941 NH2 5um 100A 4.0 x 150mm 5020-05535 NH2 5um 100A 4.0 x 250mm 5020-05536 NH2 5um 100A 4.6 x 150mm 5020-05545 NH2 5um 100A 4.6 x 250mm 5020-05546 SIL-100A 3um 100A 4.0 x 150mm 5020-04235 SIL-100A 3um 100A 4.0 x 250mm 5020-04236 SIL-100A 3um 100A 4.6 x 150mm 5020-01701 SIL-100A 3um 100A 4.6 x 250mm 5020-01702 SIL-100A 5um 100A 4.0 x 150mm 5020-04335 SIL-100A 5um 100A 4.0 x 250mm 5020-04336 SIL-100A 5um 100A 4.6 x 150mm 5020-01711 SIL-100A 5um 100A 4.6 x 250mm 5020-01712
(* 전체 제품중 일부만 표기-Inertsil 전제품 공급가능) 예일테크 2008.07.18
3
RStech OptimaPak
OptimaPak
◈ Product Information
► C18 column
► C8 column
► NH2 column
► Silica column
◈ Ordering Information Phase Particle
Size Pore
Size ID X Length Part No. OptimaPak C18 5um 100A 4.6 x 150mm OP C18-51001546 OptimaPak C18 5um 100A 4.6 x 250mm OP C18-51002546 OptimaPak C18 3.5um 100A 4.6 x 150mm OP C18-31001546 OptimaPak C18 10um 100A 10 x 250mm OP C18-101002510 OptimaPak C8 5um 100A 4.6 x 150mm OP C8-51001546 OptimaPak C8 5um 100A 4.6 x 250mm OP C8-51002546 OptimaPak C8 3.5um 100A 4.6 x 150mm OP C8-31001546 OptimaPak C8 10um 100A 10 x 250mm OP C8-101002510 OptimaPak NH2 5um 100A 4.6 x 250mm OP NH2-51002546 OptimaPak Sil 5um 100A 4.6 x 250mm OP Sil-101002510
(* 전체 제품중 일부만 표기-OptimaPak 전제품 공급가능) 예일테크 2008.07.17
OptimaPak
◈ Product Information
► C18 column
► C8 column
► NH2 column
► Silica column
◈ Ordering Information Phase Particle
Size Pore
Size ID X Length Part No. OptimaPak C18 5um 100A 4.6 x 150mm OP C18-51001546 OptimaPak C18 5um 100A 4.6 x 250mm OP C18-51002546 OptimaPak C18 3.5um 100A 4.6 x 150mm OP C18-31001546 OptimaPak C18 10um 100A 10 x 250mm OP C18-101002510 OptimaPak C8 5um 100A 4.6 x 150mm OP C8-51001546 OptimaPak C8 5um 100A 4.6 x 250mm OP C8-51002546 OptimaPak C8 3.5um 100A 4.6 x 150mm OP C8-31001546 OptimaPak C8 10um 100A 10 x 250mm OP C8-101002510 OptimaPak NH2 5um 100A 4.6 x 250mm OP NH2-51002546 OptimaPak Sil 5um 100A 4.6 x 250mm OP Sil-101002510
(* 전체 제품중 일부만 표기-OptimaPak 전제품 공급가능) 예일테크 2008.07.17
2
Nacalai Cosmosil 5C18 MS-II
Cosmosil 5C18 MS-II
◈ Product Information
The COSMOSIL®5C18-MS-II column, taking advantage of a new end capping treatment can replace the COSMOSIL® 5C18-MS. The silica gel is end capped with polar groups for shielding effect, based on the chemical property of the packed silica gel to draw highly polar components from the mobile phase. As a result, the new end capping provides improved peak shape for basic compounds. The absorption of the silica gel is controlled because it does not interact with N atoms, therefore suitable for the separation of chelating compounds. Another advantage is that the 5C18-MS-II has similar retention characteristics to the 5C18-MS series: the HPLC conditions for the 5C18-MS are applicable to the newly developed column, 5C18-MS-II.
► Point
COSMOSIL® 5C18- MS-II Silica gel high purity porous spherical silica Average particle size 5µm Average pore size approx. 120Å Specific surface area approx. 300m2/g Stationary phase monomeric type octadecyl group End capping treatment near-perfect treatment Carbon content approx. 16%
► Stability under alkaline condition
The durability under extremely high pH is greatly improved at the new COSMOSIL® 5C18-MS-II compared with current COSMOSIL® 5C18-MS. Though it is possible to use under alkaline condition for a limited time, after long exposure some deterioration may occur. For long use we recommend pH 7.5 and below.
Stability under alkaline condition
Method: After the indicated length of incubation with the extremely high pH buffer, the column was washed and the effective plate number (N) for n-amylbenzene was measured.
The figure above shows the change in N as a function of incubation time. There is hardly any observed change in MS-II. On the other hand with MS when 10 hours or more passed rapid deterioration was observed.
Alkaline solution;0.02M phosphate buffer (pH10.0)
◈ Ordering Information PRODUCT NAME SIZE CODE No. COSMOSIL® 5C18-MS-II Guard Column 4.6mmI.D.x 10mm 38014-31 10mmI.D.x 20mm 38016-11 20mmI.D.x 50mm 34371-71 COSMOSIL® 5C18-MS-II Packed Column 4.6mmI.D.x 50mm 38017-01 4.6mmI.D.x 100mm 38018-91 4.6mmI.D.x 150mm 38019-81 4.6mmI.D.x 250mm 38020-41 6mmI.D.x 150mm 38021-31 6mmI.D.x 250mm 38022-21 10mmI.D.x 250mm 38023-11 20mmI.D.x 250mm 38024-01 2.0mmI.D.x 150mm 38025-91 1.0mmI.D.×50mm 02824-31 1.0mmI.D.×150mm 02896-01
(* 전체 제품중 일부만 표기-Cosmosil 전제품 공급가능) 예일테크 2008.07.16
Cosmosil 5C18 MS-II
◈ Product Information
The COSMOSIL®5C18-MS-II column, taking advantage of a new end capping treatment can replace the COSMOSIL® 5C18-MS. The silica gel is end capped with polar groups for shielding effect, based on the chemical property of the packed silica gel to draw highly polar components from the mobile phase. As a result, the new end capping provides improved peak shape for basic compounds. The absorption of the silica gel is controlled because it does not interact with N atoms, therefore suitable for the separation of chelating compounds. Another advantage is that the 5C18-MS-II has similar retention characteristics to the 5C18-MS series: the HPLC conditions for the 5C18-MS are applicable to the newly developed column, 5C18-MS-II.
► Point
COSMOSIL® 5C18- MS-II Silica gel high purity porous spherical silica Average particle size 5µm Average pore size approx. 120Å Specific surface area approx. 300m2/g Stationary phase monomeric type octadecyl group End capping treatment near-perfect treatment Carbon content approx. 16%
► Stability under alkaline condition
The durability under extremely high pH is greatly improved at the new COSMOSIL® 5C18-MS-II compared with current COSMOSIL® 5C18-MS. Though it is possible to use under alkaline condition for a limited time, after long exposure some deterioration may occur. For long use we recommend pH 7.5 and below.
Stability under alkaline condition
Method: After the indicated length of incubation with the extremely high pH buffer, the column was washed and the effective plate number (N) for n-amylbenzene was measured.
The figure above shows the change in N as a function of incubation time. There is hardly any observed change in MS-II. On the other hand with MS when 10 hours or more passed rapid deterioration was observed.
Alkaline solution;0.02M phosphate buffer (pH10.0)
◈ Ordering Information PRODUCT NAME SIZE CODE No. COSMOSIL® 5C18-MS-II Guard Column 4.6mmI.D.x 10mm 38014-31 10mmI.D.x 20mm 38016-11 20mmI.D.x 50mm 34371-71 COSMOSIL® 5C18-MS-II Packed Column 4.6mmI.D.x 50mm 38017-01 4.6mmI.D.x 100mm 38018-91 4.6mmI.D.x 150mm 38019-81 4.6mmI.D.x 250mm 38020-41 6mmI.D.x 150mm 38021-31 6mmI.D.x 250mm 38022-21 10mmI.D.x 250mm 38023-11 20mmI.D.x 250mm 38024-01 2.0mmI.D.x 150mm 38025-91 1.0mmI.D.×50mm 02824-31 1.0mmI.D.×150mm 02896-01
(* 전체 제품중 일부만 표기-Cosmosil 전제품 공급가능) 예일테크 2008.07.16
1
Nacalai Cosmosil 5C18 AR-II
Cosmosil 5C18 AR-II
◈ Product Information
The majority of chromatographers use reversed phase silica-based HPLC columns due to their excellent retention characteristics, high theoretical plate number, good cost-performance and ease of use. C18 or ODS reversed phase columns are the most general and popular types. Monomeric and polymeric types are available differing considerably in their retention characteristics.
Nacalai has been offering the monomeric type COSMOSIL® 5C18-MS and the polymeric type COSMOSIL® 5C18-AR columns, both well received by many chromatographers due to their excellent performance. However, the COSMOSIL® 5C18-AR-II can be used for a wider range of compounds than other polymeric types of columns already in use.
► Point
COSMOSIL® 5C18- AR-II Silica gel high purity porous spherical silica Average particle size 5µm Average pore size approx. 120Å Specific surface area approx. 300m2/g Stationary phase polymeric octadecyl group End capping treatment near-perfect treatment Carbon content approx. 17%
► Characteristics
The COSMOSIL® 5C18-AR-II packed column features a polymeric and near-perfectly end capped type of C18 reversed phase material that employs an ultra-pure silica gel low in metal impurities. In addition, it has stronger acid resistance than the COSMOSIL® 5C18-AR. The COSMOSIL® 5C18-AR-II column is especially effective for the separation of chelating compounds as well as both acidic and basic compounds.
This series of columns is also highly recommended for a wide range of applications particularly in situations where monomeric-type column (for instance, COSMOSIL® 5C18-MS-II) is not as effective as expected.
► Acid resistance
The acid resistance of COSMOSIL® 5C18-AR-II is much improved compared with 5C18-AR. It retains high performance even in case of acidic mobile phase used to separate proteins and peptides.
◈ Ordering Information PRODUCT NAME SIZE CODE No. COSMOSIL® 5C18-AR-II Guard Column 4.6mmI.D.x 10mm 38141-61 10mmI.D.x 20mm 38148-91 20mmI.D.x 50mm 34479-81 28mmI.D.x 50mm 34363-81 COSMOSIL® 5C18-AR-II Packed Column 4.6mmI.D.x 50mm 38142-51 4.6mmI.D.x 100mm 38143-41 4.6mmI.D.x 150mm 38144-31 4.6mmI.D.x 250mm 38145-21 6mmI.D.x 150mm 38146-11 6mmI.D.x 250mm 38147-01 10mmI.D.x 250mm 38149-81 20mmI.D.x 250mm 38150-41 28mmI.D.x 250mm 34362-91 2.0mmI.D.x 150mm 37992-51 1.0mmI.D.×50mm 02955-21 1.0mmI.D.×150mm 02951-61
(* 전체 제품중 일부만 표기-Cosmosil 전제품 공급가능) 예일테크 2008.07.16
Cosmosil 5C18 AR-II
◈ Product Information
The majority of chromatographers use reversed phase silica-based HPLC columns due to their excellent retention characteristics, high theoretical plate number, good cost-performance and ease of use. C18 or ODS reversed phase columns are the most general and popular types. Monomeric and polymeric types are available differing considerably in their retention characteristics.
Nacalai has been offering the monomeric type COSMOSIL® 5C18-MS and the polymeric type COSMOSIL® 5C18-AR columns, both well received by many chromatographers due to their excellent performance. However, the COSMOSIL® 5C18-AR-II can be used for a wider range of compounds than other polymeric types of columns already in use.
► Point
COSMOSIL® 5C18- AR-II Silica gel high purity porous spherical silica Average particle size 5µm Average pore size approx. 120Å Specific surface area approx. 300m2/g Stationary phase polymeric octadecyl group End capping treatment near-perfect treatment Carbon content approx. 17%
► Characteristics
The COSMOSIL® 5C18-AR-II packed column features a polymeric and near-perfectly end capped type of C18 reversed phase material that employs an ultra-pure silica gel low in metal impurities. In addition, it has stronger acid resistance than the COSMOSIL® 5C18-AR. The COSMOSIL® 5C18-AR-II column is especially effective for the separation of chelating compounds as well as both acidic and basic compounds.
This series of columns is also highly recommended for a wide range of applications particularly in situations where monomeric-type column (for instance, COSMOSIL® 5C18-MS-II) is not as effective as expected.
► Acid resistance
The acid resistance of COSMOSIL® 5C18-AR-II is much improved compared with 5C18-AR. It retains high performance even in case of acidic mobile phase used to separate proteins and peptides.
◈ Ordering Information PRODUCT NAME SIZE CODE No. COSMOSIL® 5C18-AR-II Guard Column 4.6mmI.D.x 10mm 38141-61 10mmI.D.x 20mm 38148-91 20mmI.D.x 50mm 34479-81 28mmI.D.x 50mm 34363-81 COSMOSIL® 5C18-AR-II Packed Column 4.6mmI.D.x 50mm 38142-51 4.6mmI.D.x 100mm 38143-41 4.6mmI.D.x 150mm 38144-31 4.6mmI.D.x 250mm 38145-21 6mmI.D.x 150mm 38146-11 6mmI.D.x 250mm 38147-01 10mmI.D.x 250mm 38149-81 20mmI.D.x 250mm 38150-41 28mmI.D.x 250mm 34362-91 2.0mmI.D.x 150mm 37992-51 1.0mmI.D.×50mm 02955-21 1.0mmI.D.×150mm 02951-61
(* 전체 제품중 일부만 표기-Cosmosil 전제품 공급가능) 예일테크 2008.07.16
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