Thermo Scientific
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Thermo ScientificHypersil GOLD Column
◈ Product Information
Hypersil GOLD columns are based on improved, highly pure silica and a novel proprietary derivatization and endcapping procedure using alkyl chain chemistry.
Enhanced Resolution
Robust assay development requires a clear definition of resolution expectations. Narrow symmetrical chromatographic peaks ensure that optimum resolution is achieved. Obtaining narrow peak widths is especially challenging for basic pharmaceutical compounds. The reduced silanol activity on Hypersil GOLD columns reduces tailing for basic analytes, thus improving resolution.
Improved Sensitivity
Outstanding peak shape results in greater sensitivity. When peaks exhibit tailing, peak height is reduced, therefore compromising the sensitivity of the analysis. The highly symmetrical peaks provided by Hypersil GOLD columns enhance peak height and allow for optimised peak integration calculations. This can be particularly critical when low concentrations of an analyte are present, for example in an impurity assay.
Reproducibility
Our Hypersil GOLD columns are exceptionally reproducible for reliable chromatography, column after column. This allows the user to be confident that assays developed with Hypersil GOLD columns will be robust and stable for the life of the assay, making them an ideal choice for new method development.
pH Stability
Our Hypersil GOLD columns are well suited to extended pH applications and have been shown to produce robust assays at high pH. At low pH, excellent column stability and reproducibility are illustrated over 1500 injections at pH 1.8.
► Details
- Significant reduction in peak tailing while retaining C18 (USP L1) selectivity
- Excellent resolution, efficiency and sensitivity
- Confidence in the accuracy and quality of analytical data
- 1.9um particle size columns can be used to improve speed and efficiency
► Specifications
- Particle Size : 1.9, 3, 5, 8, 12µm
- pH [Range] : 1 to 11
- Pore Size : 175Angstroms
- Carbon Load : 10%
- Endcapped : Yes
- USP Type : L1
► Ordering Information
Thermo ScientificHypersil GOLD Column
◈ Product Information
Hypersil GOLD columns are based on improved, highly pure silica and a novel proprietary derivatization and endcapping procedure using alkyl chain chemistry.
Enhanced Resolution
Robust assay development requires a clear definition of resolution expectations. Narrow symmetrical chromatographic peaks ensure that optimum resolution is achieved. Obtaining narrow peak widths is especially challenging for basic pharmaceutical compounds. The reduced silanol activity on Hypersil GOLD columns reduces tailing for basic analytes, thus improving resolution.
Improved Sensitivity
Outstanding peak shape results in greater sensitivity. When peaks exhibit tailing, peak height is reduced, therefore compromising the sensitivity of the analysis. The highly symmetrical peaks provided by Hypersil GOLD columns enhance peak height and allow for optimised peak integration calculations. This can be particularly critical when low concentrations of an analyte are present, for example in an impurity assay.
Reproducibility
Our Hypersil GOLD columns are exceptionally reproducible for reliable chromatography, column after column. This allows the user to be confident that assays developed with Hypersil GOLD columns will be robust and stable for the life of the assay, making them an ideal choice for new method development.
pH Stability
Our Hypersil GOLD columns are well suited to extended pH applications and have been shown to produce robust assays at high pH. At low pH, excellent column stability and reproducibility are illustrated over 1500 injections at pH 1.8.
► Details
- Significant reduction in peak tailing while retaining C18 (USP L1) selectivity
- Excellent resolution, efficiency and sensitivity
- Confidence in the accuracy and quality of analytical data
- 1.9um particle size columns can be used to improve speed and efficiency
► Specifications
- Particle Size : 1.9, 3, 5, 8, 12µm
- pH [Range] : 1 to 11
- Pore Size : 175Angstroms
- Carbon Load : 10%
- Endcapped : Yes
- USP Type : L1
► Ordering Information
| Hypersil GOLD Column | ||||||
| Particle Size |
Length (mm) |
4.6mm ID | 4.0mm ID | 3.0mm ID | 2.1mm ID | 1.0mm ID |
| 1.9um | 20 | - | - | 25002-023030 | 25002-022130 | 25002-021030 |
| 30 | - | - | 25002-033030 | 25002-032130 | 25002-031030 | |
| 50 | 25002-054630 | - | 25002-053030 | 25002-052130 | 25002-051030 | |
| 100 | - | - | 25002-103030 | 25002-102130 | 25002-101030 | |
| 150 | - | - | - | 25002-152130 | - | |
| 200 | - | - | - | 25002-202130 | - | |
| 3um | 30 | 25003-034630 | 25003-034030 | 25003-033030 | 25003-032130 | 25003-031030 |
| 50 | 25003-054630 | 25003-054030 | 25003-053030 | 25003-052130 | 25003-051030 | |
| 100 | 25003-104630 | 25003-104030 | 25003-103030 | 25003-102130 | 25003-101030 | |
| 150 | 25003-154630 | 25003-154030 | 25003-153030 | 25003-152130 | 25003-151030 | |
| 5um | 30 | 25005-034630 | 25005-034030 | 25005-033030 | 25005-032130 | 25005-031030 |
| 50 | 25005-054630 | 25005-054030 | 25005-053030 | 25005-052130 | 25005-051030 | |
| 100 | 25005-104630 | 25005-104030 | 25005-103030 | 25005-102130 | 25005-101030 | |
| 150 | 25005-154630 | 25005-154030 | 25005-153030 | 25005-152130 | 25005-151030 | |
| 250 | 25005-254630 | 25005-254030 | 25005-253030 | 25005-252130 | 25005-251030 | |
| 8um | 150 | 25008-154630 | - | - | - | - |
| 250 | 25008-254630 | - | - | - | - | |
| Hypersil GOLD Drop-in Guard Cartridges(pk/4) | ||||||
| Particle Size |
Length (mm) |
4.0mm ID | 4.6mm ID | 3.0mm ID | 2.0mm ID | 1.0mm ID |
| 3um | 10 | 25003-014001 | 25003-014001 | 25003-013001 | 25003-012101 | 25003-011001 |
| 5um | 10 | 25005-014001 | 25005-014001 | 25005-013001 | 25005-012101 | 25005-011001 |
| UNIGUARD Direct-Connect Drop-in Guard Cartridge Holder (ea/1) |
850-00 | 850-00 | 852-00 | 852-00 | 851-00 | |
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